Koltunova O. The influence of the parent's tobacco smoking on the development and becoming of their offspring-female reproductive function

Object of study: offspring-female, whose parents were subjected to chronic effects of tobacco smoke. Objective: to research long-term consequences of parent's chronic tobacco smoke on the development and becoming of their female offspring reproductive system and their sex behavior.. Methods: A technique for modeling of chronic intoxicity of tobacco; ethological, linked immunosorbent assays; morphometric; karyometric; mathematical, statistical. Theoretical and practical results, novelty: For the first time long-term effects of chronic intoxication with tobacco smoke of the parents was conducted on the formation of the reproductive systems of their offspring-female from birth to sexual maturity at different modeling of parent pair's smoking. The chronic inhalation of parents by tobacco smoke in the offspring resulted to the phenomenon of accelerated development in all experimental groups, to variations in the manifestation of emotional reactions in the behavioral test "open field". For the first time in experimental material was shown that variations in morphofunctional state of reproductive glands of offspring-female was already in the prepubertal age combined with a change in the compensatory-adaptive features of these glands and their hormone-dependent tissues and organism in a whole. It was shown that in the reproductive age for the offspring-female were characterized by variations in the duration and the phase structure of the estrous cycle, hormonal status, which led to decompensation of both central and peripheral parts of the regulation of sexual behavior. Field of application performance: The findings are important for the development of prognostic criteria for the risk of reproductive disorders in expectant mothers whose parents smoked in different ways. The study can be recommended for inclusion in the course of anatomy, physiology, histology, obstetrics and gynecology, drug treatment, pediatrics, sexual pathology, hygiene and discipline and should be the basis to develop new aspects of tobacco and drug prevention.