Efimova N. Estimation of tobacco smoking as risk factor in the development and progressing of chronic obstructive pulmonary disease

Object of the research. Chronic obstructive pulmonary disease. The purpose of the research. The increase of prophylaxis, diagnosis and therapy of COPD efficiency. Methods. Questionnaire, clinical, functional, immuno-fermental, statistical. Theoretical and practical findings. The peculiarities of nicotine-dependent smoking habits in patients with COPD are shown up. It has been proved that the progress of the disease symptoms, bronchial obstructive impairments and hypoxia increasing are associated with smoking factor. It has been determined that COPD forms endothelial dysfunctions which are complicated depending on smoking, disease duration, presence of the accompanying hypertension as well as the patients' age. It has been shown that the taking inhalation glucocorticosteroids has decrease the development of the disease in patients with the third and the fourth stages of COPD. Novelty. Peculiarities of smoking habit in smokers with COPD have been revealed. The progress of clinical and functional manifestations of COPD on the background of smoking has been established. The influence of prolonged smoking and COPD on endothelial dysfunction development has been proved. The conditions of the endothelial dysfunction progress have been established. The positive influence of the glucocorticosteroids inhalation therapy on expressiveness of endothelial dysfunction in patients with the third and the fourth stages of the disease have been shown. Additional administrations for introduction of antismoking programme among the smokers with COPD have been proved. Stage of introduction. Articles, theses, including in the medical educational programms. Sphere of use. Medicine.