Sak A. Ages peculiarities of structure organization of lumbar intervertebral disk at the various conditions of motor activity (anatomo-experiment research)

Thesis devoted to the study of structural organization of lumbar intervertebral disks of white rats-males under conditions of normal-, hypo- and hyperkinesia in aged aspect. Macro-microscopic, morphometric, histological, polarization-optical, histoenzymologic and mathematical methods of research were used. It is established, that intervertebral disks and bodies of vertebrae of rats have the certain features of structure, which represent the type of rats' locomotion. It is shown that under conditions of hypokinesia the processes of tissue senescence of disks are accelerated, the apoptic changed cells come to light in a fibrous ring. It is confirmed by the results of electronic microscopic researches. It is well-proven by histoenzymological experiments, that these changes are accompanied by the declining of activity of enzymes oxidizing phosphorylating and the increase of activity of enzymes of glicolysis. The aged features of adaptations damages of intervertebral disks are set in the conditions of the protracted dynamic loading. The disks of non-fullagedanimals have higher reactivity. It is shown that the high physical loading damages the elements of intervertebral disks, apophisis of bodies of vertebrae and plate of growth. It is first well-proven that one of indexes of dystrophic damages of disks in the conditions of hyperkinesia can be a change of gradient of activity of іzoenzymes of LDG in the cages of fibrotic ring with falling of activity of aerobic izoforms and increase of activity of anaerobic іzoforms of LDG. Under the conditions of hypokinesia alterations of disk are begun with a swampy kernel, and in the conditions hyperkinesia from alteration of fixing areas of disk to the bodies of vertebrae with subsequent violation of this connection.