Rabyk M. Regulatory mechanisms of negative type involved in moenomycin biosynthesis in actinomycetes

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U001424

Thesis Registration Form

0412U001424.pdf

Applicant for

Specialization

  • 03.00.15 - Генетика

23-02-2012

Specialized Academic Board

Д 26.202.01

Essay

Genes encoding putative negative regulators of moenomycin biosynthesis in S. ghanaensis were identified, cloned and studied. In vivo titration of moeO5p and moeE5p showed that they are subject to transcription regulation by positive regulators. Genes atrAgh and nsdAgh do not exert significant effects on moenomycin production under overexpression conditions in S. ghanaensis. Gene absA2gh encodes response regulator of two-component system AbsAgh1/2 in S. ghanaensis and negatively regulates moenomycin production. Overexpression of ppkgh in S. ghanaensis leads to reduced moenomycin production. WblAgh is negative regulator of moenomycin biosynthesis and plays an important role in morphological differentiation of S. ghanaensis.

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