Kuzenko Y. Morphological changes in enamel due to the combined effects of heavy metal salts

The investigation object: The thesis deals with morph functional features of the enamel secreting apparatus in rats under the influence of simulated microelements, searching the ways to correct the identified changes. The investigation goal: The determination of the morphological features of amelogenesis and mineral composition of enamel, formed in experimental animals under the influence of heavy metals and their comparison with the results of clinical examination of patients for dental caries. Methods of research: Morphological changes have been studied by means of morphological and metric measurements of enamel secreting apparatus in rats; light microscopy techniques morph metrology, electron microscopy, chemical analysis, mathematical and statistical data. Theoretical and practical value of the obtained results. In the experiment revealed anameloblastov response of white rats on the effect of salts of heavy metals. The data obtained can be used for morphological study morphological changes in enamel occurred in Orthopaedic clinic and dentistry, effect relationships in man-made effects on the body mikroelementoz. We have created an experimental model can be further used to study other adverse environmental factors on amelogenesis. The data obtained can be the basis for seeking the correction of structural changes in enamel and new ways to prevent adverse environmental factors, as well as to find new ways to odontoprotekt. Scientific novelty of the obtained results: It has been found out that microelements have arisen minor changes in the enamel immature rats and at a mature age, which has appeared in the form of increased the spaces in the enamel and reduced enamel prisms. The edema has been observed in the layer of anameloblast. The degree of transformation and expression are dependent on the duration of the influence of microelements and the age of the animals. Our studies have revealed a significant accumulation of heavy metal ions in the enamel, which is more intense in the oral fluid. The use of acidum thiocticum reduces damaging processes in enamel synthesizing apparatus of rats. The degree of implementation: The results of the study have been introduced into the educational process at the Department of Human Anatomy of higher medical education, at the Department of Applied Ecology in Sumy State University.