Аbdulahad Q. Influence of multiprobiotics of group "Symbyter" on gastric secretory function in rats under prolonged hypergastrinaemia

Object: mechanisms of functioning of secretory apparate of stomach. Objective: the secretory function of stomach upon long-term hypergastrinemia evoked by Н+-К+-АТPase blocker omeprasole and correction of consequences of long-term injection of omeprasole by multiprobiotic. Methods: physiology(research of basale and stimulated secretion of acid is in the stomach of rats, determination of products of degradation of collogen and uncollogen протективних proteins of mucous-ephithelial barrier), microbiological(quality and quantitative indexes of microflora of stomach), radioimmunological, spectrophotometrical and methods of statistical analysis. Results: It was established that long-term hypoacidity in rats evoked by omeprasole leads to strongly pronounced increase of gastrin blood level and disbacteriosis in the stomach. Simultaneous injection to the rats omeprasole and multiprobiotic "Symbiter forte" leads to diminish of gastrin blood level. Multiprobitics prevented the development of disbacteriosis in the stomach and decreased basal and stimulated by carbachol gastric acid secretion. that hyperplasia in gastric mucosa evoked at least two ways. The first way is the influence of hypergastrinemia, the second - the influence of disbacteriosis. In a day after 28 days of omeprasole injection pro-/antioxidant system in gastric mucosa disbalanced and the levels of free oxyprolin, fucose and hexuronic acid were increased. Multiprobiotics to a certain extent prevented such changes. We concluded that hyperplasia in gastric mucosa evoked at least two ways. The first way is the influence of hypergastrinemia, the second - the influence of disbacteriosis. Scope of use: physiology, pharmacology.