Theses cover the research of modern hand rub antiseptics and different types of disinfectants that are presented on the Ukrainian market from the standpoint of their optimal choice and application conditions. In the paper identified basic criteria and developed algorithms of pharmacoeconomic choice of hand antiseptics and different types of disinfectants for solving specific pharmacoepidemiological and disinfectological problems. It is based the necessity of introduction in Ukraine the unified system of standards for an objective and reliable assessment of the effectiveness of hand antiseptics and disinfectants. Deep analysis of modern disinfectants showed that the common number of active substances, that can be used in their formulations is quite limited. This leads to the fact that now appear "know-how" in disinfection technologies, which allow to change microbiological efficacy of disinfectants, their regimes of use, ecological and human safety only by using secondary ingredients of different kind. During the study of hand antiseptic market, special attention was paid to the confirmation of product's preventive action and safety, declared in accordance with the defined regulatory category. It was found that products, which have status of medicines and disinfectants mostly correspond to expectations and requirements of customers. In order to optimize the pharmacoeconomic and pharmacoepidemiological analysis of antiseptics and disinfectants, as well as to make the choice easy, was developed an analytical application electronic data base "Analysis of disinfectants and antiseptics that are registered in Ukraine according to priority factors " (hereinafter "Electronic database"). Potential of the electronic database first of all allows to analyze and select antiseptics and disinfectants according to specific conditions that are set when forming a pharmacoeconomic task: correspondence to European norms, active substances, exposure time, the number of liters in packaging, microbiological activity, price, etc. Secondly, it allows sorting the selected products according to priority requirements of a customer. Results of questionnaire brought to light a significantly low level of professional knowledge and attention of pharmaceutical and health care workers to the choice and proper use of hand antiseptics and disinfectants. The most of well known mistakes in the hand hygiene practice and new mistakes identified by the study, were systematized and grouped. Meanwhile it is proved that even the optimal choice of a hand antiseptic can ensure the maximum efficiency from its use only in conditions of high status of hand hygiene in health care and pharmaceutical organizations and staff compliance to the corresponding procedures. In this regard, was developed a hypothetical version of good hand hygiene implementation in health care institutions and drug manufacturing enterprises. According to the identified factors that block the formation of hand hygiene compliance of healthcare and pharmacy workers it was proposed the differentiation of methods and measures of compliance optimization. The ways to prevent mistakes in the hand hygiene practice according to the specifics of professional activity of healthcare workers were proposed. Also it was created instructional and methodological framework for good hand hygiene promotion and improvement for medical and pharmaceutical staff, particularly the following documents were developed: methodic recommendations 'Surgical and Hygienic Hand Treatment of Medical Workers' approved by Order № 798 of the Ministry of Health of Ukraine of September 21, 2010; instructions and methodic recommendations 'Collection of Regulations, Professional Skills Characteristics, Job Descriptions of Pharmaceutical Staff'; Information sheet 'Optimization of Staff Compliance to Good Hand Hygiene and to Use of Means for Hygienic Hand Treatment'; 'Hands Passport' for control of hand antiseptic procedure. The low level of staff compliance and different mistakes in hand hygiene practice, that were registered during the research, gave the reason to design and conduct training programs for good hand hygiene on the basis of medical institutions, pharmacies, advanced training courses, etc. It was proved that the optimal way of teaching staff the proper hand hygiene is to carry out regular master-classes and trainings on application of hand antiseptics with further control, self-control using ultraviolet boxes and special fluorescent solutions. The results obtained after the first training session, that was the part of the study, showed that the number of workers with fixed untreated after the antiseptic treatment areas of hand skin has decreased from 60% to 10-15% The pilot study which was carried out on the basis of one of domestic Scientific-Manufacturing Enterprises (SME) confirmed the sanitary, epidemiological and economic reasonability of spending budget funds of health care and pharmaceutical organizations for purchasing the high quality alcohol hand rub antiseptics. During the period of an active promotion of hand antiseptic with corresponding trainings, monitoring of hand rub implementation and regular supply of SME stuff with high quality alcohol hand rub products, the number of workdays missed by employees because of respiratory infections and influenza decreased by half in comparison with the analogous period of passive hand antiseptic maintenance. Budget money saved due to reducing of payments of respiratory infections and influenza sick-lists of employees, not only covered the costs of the high quality alcohol hand rub antiseptics, but also confirmed the economic benefit from the implementation of routine hand antiseptic on the workplaces. Each grivna spent on the introduction of appropriate hand antiseptic, allowed to save 4.5 grivna only on payment of sick-lists.
