Volyanska N. Development of vaccine preparation based on the acylated immunogenic derivatives of biopolymers from P.aeruginosa

On the basis of surface antigens P.aeruginosa 66-16 by acylation returned substance has high glycoproteides. Investigated in the experiment the immunogenicity of antigens 48 samples of different degree of acylation, 12 of them were selected for constructing anti-pseudomonas vaccines. As carriers of antigens used liposomes of 50 nm m.m.900 Da. The degree of accumulation lecithin’s liposomes in the cells of reticulo-endothelial system of animals. The vaccine is stabilized by ascorbinate Na, protected by conservant - benzoate Na. A two dosage forms of vaccine - for transdermal and oral delivery. The stability and sensitizing properties of the vaccine preparation. Normative and technical documentation, specifications and project pharmacopoeial article for two dosage forms vaccine (transdermal and oral).