Cheretaev I. Features of electric potentials of Helix albescens Rossm. mollusсs neurons at the action of standard and newly synthesized salicylates

The study found that acetylsalicylic acid at concentrations of 0,5*10-4 and 0,5 * 10-3 M selectively and reversibly inhibits the functional state of neurons and in a concentration of 0,5*10-2 M causes a complete disappearance their impulse activity. It is shown that acetylsalicylate cobalt and zinc have an activation-modulating effect on the electrical activity of neurons. It is found that calcium ions do not take a significant part in neurotropic effects of salicylates. It is shown that addition of extracellular adenosinetriphosphate significantly alters the electrical potentials in neurons of salicylates. It was found that acetylsalicylic acid at a concentration of 10-3 M reversibly slow interneuronal transmission, and the concentration of 10-2 M causes its irreversible depression. It also determined that acetylsalicylates of cobalt and zinc in a concentration of 10-3 M facilitate transsynaptic signaling in neurons of the cochlea, and the concentration of 10-2 M irreversibly inhibit.