Grintsova N. Morphologic and cytochemical changes in the brain tissue of rats under the impact on the body of heavy metals (anatomical and experimental study)

The thesis deals with the morphological and cytochemical features of the restructuring and changes in the chemical composition of the tissues of the cerebral cortex of rats in conditions of a combination of heavy metals in the subacute experiment and find ways to correct the identified changes. Structural changes in the brain tissue was studied using organometrical measuring light microscopy methods marine fometrii, fluorescence microscopy (cytochemical method), by electron microscopy, chemical analysis, and statistical analysis. Found that the combination of heavy metals investigated lead to structural and morphological reorganization of the cortex tissue in the form of violations of the permeability barrier gematoentsefalic for heavy metals, microcirculatory disorders, active proliferative processes by glia cells, atrophic and destructive changes of neurons, their nuclei, impaired protein. After the cessation of effect of metal body structure is completely restored. Application of metabolic drug "Glutargin" can improve recovery processes in the brain of experimental animals.