Bashura A. Development of technology and gel infusion of leaves of Horse Chestnut.

Dissertation is devoted to development on the basis of Horse Chestnut. The technology of Horse Chestnut leaves tincture has been developed for the first time and experimentally grounded. The physical and chemical properties of the developed drug have been studied, methods of qualitative and quantitative analysis of active substances have been proposed, storage conditions and shelf life of the Horse Chestnut leaves tincture have been defined. Specific (anticoagulation, protrombinoformation, membranostabilisation, anti-inflammatory) activity of the Horse Chestnut leaves tincture and lack of toxicity have been experimentally determined. The composition and technology of gel containing the Horse Chestnut leaves tincture and essential oils have been developed and scientifically grounded according to the results of physico-chemical, structural, mechanical, biopharmaceutical and biological researches. The specific activity and biological safety of the gel have been studied. The physical and chemical properties of the developed gel have been studied, storage conditions and shelf life have been grounded..