Kukhtenko H. Development of technology and cream with methylprednisolone aceponatom.

The thesis is devoted to the development of the composition and technology of a medicine in the form of a cream containing glucocorticosteroid methylprednisolone aceponate. On the basis of complex physical-chemical, structural- mechanical, biopharmaceutical and microbiological research techniques the composition of the cream on a hydrophilic emulsion base has been scientifically justified. Quality indicators have been established and methods of their determination have been proposed, defined form of primary packaging, storage conditions and shelf life of the cream "Sterokort." Pharmacological studies have established specific pharmacological activity of the drug, Toxicological studies have proved its safety. Registration for the medicinal product № UA/7784/01/01 has been received and the preparation has been implemented in mass industrial production at РSC "Phytopharm", the city of Artyomovsk.