Tkachenko G. Effect of hypokinesia on some physiological functions that characterize hemodynamics and antioxidant systems in young adults and in experiment

The object of study - functional status and hemodynamics of youth (students) under different levels of physical activity. Structural and metabolic parameters in rats with experimental hypokinesia modeling. The aim of study: to study the physiological characteristics of functional status, hemodynamics and biochemical indicators in social and experimental hypokinesia to support and develop ways to prevent the physiological imbalance. Methods: anthropometry, arterial tonometry, pulsometry by R. M. Baevskiy, indirect determination of maximum oxygen consumption, assessment of a simple visual-motor response, testing, surveys, methods of enzyme activity and the content of metabolites biochemical analysis, spectrophotometric, colorimetric, fluorometric, histologic, statistical analysis. Theoretical and practical results, novelty: social hypokinesia among students reduces the maximum volume of oxygen consumed. The most important manifestation of hypokinesia is reducing body functional reserves. Based on studied hemodynamic parameters, autonomic heart rate regulation, maximum oxygen volume and anthropometric measure the integral adaptive capacity of the human body was proposed. In the experimental model with a 16-day hypokinesia quantitative changes of prooxidant-antioxidant parameters was found. Increasing the level of TBA-active products was associated with decreased concentrations of low molecular weight antioxidants, increased concentration of ceruloplasmin, superoxide dismutase activity in serum. Hypokinesia in rats caused a reduction of vitamins A, E and glutathione in the liver and an increase in superoxide dismutase activity in the liver and heart. Observed a decrease in the concentration of adenosine triphosphate in the liver and heart and liver glycogen while increasing the activity of enzymes - markers of cell damage in the blood and severe morphological changes of hepatocytes. Field of application: research work on the study of hemodynamics and antioxidant systems in hypokinesia in humans and in the experiment, teaching of physiology of physical activity.