Vasyleva I. Features of neurohumoral status in rаts with dominant and submissive types of behaviour

Dissertation is devoted to investigation of relationship between hormones of gonadal, hypothalamic-pituitary-adrenal, thyroid axes and monoaminergic system components in rats with dominant and submissive types of behaviour. The dependence of male behaviour type on testosterone level was revealed. The tight negative correlation between testosterone and 17beta-estradiol in blood plasma was shown in all investigated groups. Hyperactivity of HPA system was found in submissive animals. The presence of tight negative correlation between testosterone level and HPA system hormones (ACTH and corticosterone) was shown in rat males independly of age and behaviour type, which is evidence of testosterone participation in HPA system organization and inhibition influence of testosterone on this system. The decrease of serotonin content in frontal cortex and hyppocamp in submissive males and positive correlation between testosterone and serotonin in submissive and dominant males of young reproductive period instead of negative correlation in steady animals were revealed. Last one in complex with testosterone changing is one of the components of submissive of dominant behaviour type formation. Increased noradrenaline level in submissive males and decreased noradrenaline level in dominant ones, positive correlation between noradrenaline and HPA system hormones were revealed. That is evidence of different role of noradrenaline in development of spontaneous and adaptive aggression.