Object of study - hepatodystrophy in sheep . The study - the study of the pathogenesis of liver damage in sheep , the development of methods for early diagnosis and informative , and effective treatment of sick animals. Methods - clinical , morphological (number of erythrocytes and leukocytes) and biochemical blood parameters ( hemoglobin , total protein , protein fractions , urea, creatinine , glucose, total and conjugated bilirubin, kon'yuhantiv diene , lipid hydroperoxides , TBA- active products , active aspartic and alanine aminotransferase , gamma- glutamyl , alkaline phosphatase ), histological ( liver biopsy ), scatological method ( sequential washing) and statistics . Scientific novelty of the results. For the first time in sheep studied symptoms indicators biloksyntezuvalnoyi , age , urea and kreatyninoutvoryuvalnoyi , carbohydrate function , activity indicator enzymes and liver structure , content, products of lipid peroxidation by experimentally simulated disease ( toxic hepatodystrophy ). Investigated etiologic factors and pathogenetic mechanisms of hepatodystrophy in sheep. For the first time the products of lipid peroxidation ( diene kon'yuhanty , lipid hydroperoxides , TBA- active products ) in the blood of sheep and shown their importance in the pathogenesis of the disease. The structure and functional state of the liver in sheep suffering from hepatodystrophy , allowing us to offer informative diagnostic methods. Investigated the functional state of the liver in sheep suffering from Fasciolosis . For the first time found that the use of sheep anti- drug Rolenol causes deterioration of the functional state of the liver. Experimentally and theoretically grounded new and improved existing treatments for sheep liver disease . Ukraine received a patent for utility model number 36716 " A method of treating sheep with liver pathology ." The results are used in scientific and academic work in the department of internal medicine and animal clinical diagnosis Lviv National University of Veterinary Medicine and Biotechnologies named after SZ Gzhytsky , internal diseases and physiology of Zhytomyr National Agroecological University , Department of Therapy Poltava State Agrarian Academy , the Department of internal diseases Lugansk National agrarian University , Department of pathology and Parasitology noncontagious South branch of the National University of Life and Environmental Sciences of Ukraine «Crimean Agricultural University", the department of clinical diagnosis and therapy Bilotserkivskyi National Agrarian University , Department of clinical Diagnostics and Clinical biochemistry Kharkiv State Veterinary Academy , Department of internal Medicine and animal hygiene animal Podolski State Agricultural and technical University. Field of application: veterinary medicine.
