Kisel'ov V. White rats’ adrenal glands morphological and functional changes as a result of in vivo taken xenogenic cerebrospinal fluid administration

The thesis was to study of different age white rats’ adrenal glands morphofunctional status under the influence of xenogenic cerebrospinal fluid parenteral administration, in dependence on the multiplicity of its introduction. Separately were studied morphological changes of adrenal glands of rats previously treated with the drug product itraconazole, to reduce the adrenal cortex activity, and which, after a while were also parenterally administered xenogeneic CSF. The experiment had been performed on 84 male white rats with the results assessment by bio- and organometric, histological and ultra-microscopic, biochemical and statistical methods. The study found that three-times CSF administration leads to functional activation in all areas of adrenal cortex with a signs of further exhaustion and overloading; 10-times introduced xenogenic CSF promotes an increase of adrenal cortex regenerative reactions and follows the malfunction signs reduction; the greater expression of those reactions is detected for adrenal zona fasciculate; 10-times introduced xenogenic CSF promotes the restoration of previously inhibited adrenal cortex’ activity.