Gafarova E. The age-related features of the liver structure after the hyper gravity exposure and protection from it

The dissertation is devoted to the study of the liver morphogenesis under the influence of exogenous factors. The purpose of the study was the comprehensive assessment of morphological changes in the liver of rats in age aspect in terms of systematic exposure of the cross-directional gravitational overloads without and with the use of various methods of protection. Methods of investigation: morphological methods - macroscopic (descriptive macroscopic, organometric), histological methods (hematoxylin and eosin, Van Hisone, PAS- reaction), histomorphometric, cytomorphometric method, ultramicroscopical, statistical. The theoretical importance of the obtained results is in the establishment of the spectrum of histopathological changes in the liver after the systematic exposure of gravitational overloads that represents the basic pathogenetic vectors of acceleration impact on the microcirculatory bed of liver parenchymal component. Extrapolating the data to the human, the results can be used for further development of pathogenetical methods of prevention and correction of the systematic negative impact of hypergravity in the flight personnel. For the first time the experimental work shows a comprehensive study of rat liver in juvenile, young and mature age periods after systematical 10 - minutes exposure to cross-directional hypergravity of 9 g within 10 and 30 days, at different levels of structural organization, as well as after the application of physical protection and pharmacological correction be the medicines Glutargin and Lipoflavon.