Gargula T. Features of remodeling of duodenum structures under conditions of chronic ulcers and action of salts of cadmium and aluminum.

The thesis is devoted to studying patterns of remodeling of structures and vascular bed of duodenum under conditions of chronic ulcers and action of salts of cadmium and aluminum. Morphological studies have established that with duodenal ulcer reduced thickness of mucous membrane and muscular layer, villus height, crypt depth, height of epithelial cells and diameter of their nuclei, increasing thickness of submucosa basis and serosa. Installed restructuring components of the wall of the duodenum with its ulcer leads to organ dysfunction. This is illustrated by increase of submucosal-mucosal, submucosal-muscular and indexes of crypt and villi, also by nuclear-cytoplasmic and ratio of stromal myocytes in epithelial cells. It is showed by the relative amounts of damaged epithelial cells and endothelial cells. Restructuring arteries of duodenum with its ulcer are dominant in the arteries of small caliber and in vessels of microvascular bed. Duodenum with its ulcer, which ran against the background of the introduction of cadmium chloride, accompanied by the most expressed structural changes. Evidences of this were increasing relative volume of damaged epithelial cells of mucous membrane and endothelial cells of the arteries of small caliber. After the introduction of aluminum chloride to the Vietnamese pig breeds it was impairment of duodenal ulcer. But these changes were less pronounced than morphogenesis of duodenal ulcer with cadmium chloride intoxication.