Miz A. Developmental anatomy of the small intestine in case of xenobiotics effects on the organism: the intestinal wall remodeling and reorganization of its vascular bed.

The thesis is devoted to investigation of remodeling peculiarities of duodenum, ileum and jejunum structures, their arterial bed depending on the age and by the action of carbon tetrachloride. The structural similarity of different parts of the small intestine in rats, and their similarity in structure to the human small intestine was established. In immature animals revealed more subtle structural organization compared to mature and old animals and the minimum number of affected epithelial cells, due to the lack of maturity of the structural components of the intestinal wall and indicates a low level of degenerative and atrophic changes in this age. By morphometric study of arteries was found that the best conditions of blood supply are in small intestine of mature rats. The lowest bandwidth arteries of unaffected small intestine was found in old rats. Age features of remodeling arteries of the small intestine are characterized by thickening of their walls, narrowing of the lumen, a slight decrease in the vessels capacity. The degenerative, destructive and infiltrative processes developed against the background of significant hemodynamic disorders, the intensity of which is reduced in the caudal direction, were observed in terms of modeled acute carbon tetrachloride intoxication in the small intestine of rats of different ages. The degree of structural changes in the wall of the small intestine and its vascular bed also depends on the age of the animals.