Bezpala Y. Development of composition and technology of combined medicine for use in dentistry

For the first time composition and rational technology of dental gel with a complex action for the treatment and prevention of inflammatory periodontal disease and oral mucosa were proposed. Using technological research of pharmacy the choice and concentration of active substances were justified: phytosolution «Rotokan» (an anti-inflammatory effect, enhances and speeds up the repair process of the mucous membranes) – 10.0%, triclosan (antimicrobial activity) – 0.4%. Based on comprehensive research, optimal composition and technology of gel «Rotrin-Dent» on the basis of phytosolution «Rotokan» and triclosan were proved. Modern methods of qualitative and quantitative determination of triclosan, the main components of phytosolution «Rotokan» and a preservative (sodium benzoate) were developed. Project of ARD for the drug was developed. The stability of the gel «Rotrin-Dent» in storage during two years at room temperature in aluminum tubas was proved. It was confirmed that the developed gel is safe (LD50> 5000 mg / kg).