Adonkina V. Theoretical and practical grounding of medicines’ cost optimizing for the prevention and treatment of cerebral circulation disorders

The thesis is devoted to the scientific and practical approach of medicines’ cost optimizing for the prevention and treatment of cerebral circulation disorders (ССD). In this work the clinical and epidemiological aspects of the condition and direction of prevention and therapy of patients with CCD were carried out; the evidence of effectiveness, the pharmaceutical market and affordability of antihypertensive, antithrombotic and neuroprotective medicines for the prevention and therapy of CD were analyzed; the dynamics of antihypertensive, antithrombotic and neuroprotective medicines consumption during 2008-2013 years in the amount of packaging, in terms of money and DDDs/1000/day were found; the rationality and cost of therapy on the basis of the ABC/VEN/frequency analysis and prescribing to patients with ischemic stroke and pharmacoeconomic analysis schemes of CCD prevention and treatment were analyzed. On the basis of the research results the recommendations for optimizing the cost of medicines in patients with CCD were developed. Obtained results are scientific and methodological base for practical medicines’ cost optimization for the prevention and treatment of CCD.