Moskalenko Y. Morphological changes in the testes during early postnatal ontogenesis under the influence of heavy metal salts (anatomical and experimental study)

TThe thesis is devoted to the morphological characteristics of testicular tissue under the influence of salts of heavy metals, to the ways of correcting the detected changes. The paper is a complex study of structural features of the immature rat testes under the influence of a combination of heavy metal compounds and their effect correction by L-carnitine. It is claimed that the effect of heavy metal compounds leads to slower growth of testes parenchymal components. The most distinct violations of structural and functional homeostasis of immature rat testes are observed after 60 days of the experiment, due to the cumulative effect of heavy metal compounds. Against the background of the impact of threshold concentrations of heavy metals the inhibition of maturation of spermatogenic epithelium and simultaneous activation of Leydig cells have been detected. The dependence of localization of the heavy metals accumulation from morphofunctional activity of the testes histological structures is revealed. Injection of L-carnitine reduces the damaging impact of heavy metal compounds on the structure of the testes of immature animals, which may indicate its potential effectiveness as a corrector of adverse changes caused by the combined effect of heavy metal compounds. The results of the paper are implemented into educational process of the Departments of Human Anatomy, Topographic Anatomy and Operative Surgery of higher medical schools.