Fishchuk L. Defining the polymorphic variants role of eNOS, PON1, AT1R, ACE, AGT genes in the formation of the cardiovascular diseases and cancer

The dissertation is devoted to study the polymorphic variants role of eNOS, PON1, AT1R, ACE, AGT genes and their inter-gene interaction in the risk of developing breast cancer and hypertension in general groups and age women subgroups. It has been revealed that the 235MT/II genotypes combination presence is association with a protective effect in the breast cancer risk in women aged 36 to 54 years. The 235TT genotype of AGT gene and 235ТТ/174TM genotypes combination аre associated with increased breast cancer risk for women older than 54 years. It was prove that the II genotype of ACE gene and 235MT/174TT/II/1166AA combination of genotypes presence decrease the risk of hypertension in women aged from 36 to 54 years. It was observe that the 235MT/ID/1166AC heterozygous genotypes combination presence increase the hypertension risk more than 10 times for women older than 54 years. The statistical significant model of inter-gene interaction in the development of breast cancer in women aged 36 to 54 years was elaborated. Key words: breast cancer, hypertension, women, gene, polymorphism.