Borovets O. Effect of estrogen on rat liver secretory function

Resulting in acute experiments in rats experimental data indicate a rather corrective effect on estrone amount of bile secreted by the liver and its composition in rats of both sexes. In this case, changes in the composition of bile after intraportal infusion estrone differ in males and females, and are not equally prevented previous intraportal administration of tamoxifen. Estrone role in the regulation of the individual units of the metabolic processes in the liver cells closely associated with bile, still remain poorly understood. They are resulting of the effectiveness of various multienzyme systems providing biosynthetic processes, hydroxylation, conjugation, esterification and other transformations of metabolites in the liver cells. In particular, estrone inputted intraportal stimulated choleresis in females, caused significant changes in the biosynthesis of conjugated bile acids in the liver of the experimental animals of both sexes, as reflected by changes in the ratio of free and conjugated bile acids in bile. Tamoxifen partially eliminates the effect of estrone on bile secreion liver function in male rats, which was reflected in a decrease in the concentration of taurocholate, glycocholate, phospholipids, cholesterol in the bile. Prolactin, and follicle stimulating hormone may be involved in the implementation of the effects of estrogen receptor ligands (estrone, tamoxifen), modifying their influence on processes to ensure cholepoiesis and composition of bile.