Ratushnyi S. The scientific development of the composition and the technology of the medicine in transdermal therapeutic system with thiamazole

A thesis is focused on the development of matrix composition and technology of the transdermal therapeutic system with thiamazole. In consequence of literature analysis the actuality and prospects of transdermal therapeutic system development was proven for the usage in medical practice. For the first time the possibility of thiamazole transdermal introduction was justified. Thiamazole's physical and chemical properties as well as analysis of its n-octanol/water partition coefficient were investigated. The optimal pH limits for the polymer structural composition of the matrix transdermal system with thiamazole are within 5,5-7,0.For the first time the structural-mechanical analysis of prospective polymer structural compositions was carried out on the Waler-Rebinder device. In vitro studies of the thiamazole release kinetics from innovative transdermal therapeutic system have been conducted in comparison with "Mercazolil-Zdorovye" tablets. A prolonged kinetics of the active substance from the transdermal system was established.