Goncharova A. Development of composition and technology of cream for use in diabetic foot syndrome.

Thesis is devoted to development of the grounded composition and technology of cream for use in diabetic foot syndrome at an early stage in order to prevent the progression of ulcerative forms of the syndrome. Theoretically the choice of emulsion basis was grounded and were studied the physicochemical and structural mechanical properties of the emulsion bases with different complexes of emulsifiers. According to the results of biological and microbiological testing concentrations of active substances were proved: ?-lipoic acid (anti-inflammatory, antioxidant effect) - 2.0 %; urea (moisturizing, moderate keratolytic action) - 10,0 %; tea tree oil (antimicrobial, preservative action) - 3.0 %. Based on multi-method research optimum composition and rational technology of the cream "Dermalipoin" were substantiated. Methods of qualitative and quantitative determination of active substances in the drug were worked out and project of ARD was developed. It was proved the cream "Dermalipoin" stability during storage for two years at room temperature in the aluminum tubes. Was confirmed that developed cream is safe.