Horokhovskyi Y. The role of Zn2+ ions in the functional changes of the mucosa of the distal part of small intestine by the action of diclofenac

Thesis is devoted to the role of Zn2+ ions in the regulation of functional changes in the inflammed mucosa of the distal small intestine, inducing by action of the nonselective cyclooxygenase inhibitor - diclofenac sodium. It was established that increase of con-centration of Zn2+ ions in a mucous membrane of a small intestine, as a result of mod-ulation of its transmembrane transport by zinc ionophore, when blocking a cyclooxygen-ase, leads to significant increase in extent of structural and hemorrhagic lessions of a muc-ous membrane of distal part of a small intestine. It is shown that transmembrane transport of Zn2+ ions modulation by zinc ionophore at state of disruption of epithelial barrier of distal part of a small intestine leads to increase in quantity of autochthonic bacteria, and to appearance of representatives of allochthonic bacteria that further is the cause of hyper activation of local antibacterial protection of a mucous membrane of a small intestine and leads to lingering inflammatory process. It is defined that the dose dependent modulation of transmembrane transport of Zn2+ ions by zinc ionophore, when blocking a cyclooxygenase, leads to increase in activity of a myeloperoxidase and increase of concentration of nitrites, and also simultaneous decrease of the activity of a superoxide dismutase and catalase in a mucous membrane of distal part of a small intestine on the 3rd - 7th days of research, than at simple blocking of a cycloox-ygenase. More considerable and long reduction of Zn2+ ions and cationic proteins in the secretory granules of Paneth cells at the state of simulaneous modulation of transmembrane transport of ions of Zn2+ against blocking of cyclooxygenase is shown, than at simple blo-cking of a cyclooxygenase.