Yasinovsky O. Remodeling chambers and vascular bed under the influence of cadmium chloride and aluminum chloride

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U004233

Applicant for

Specialization

  • 14.03.01 - Нормальна анатомія

29-06-2015

Specialized Academic Board

Д 58.601.01

I. Horbachevsky Ternopil State Medical University

Essay

In the experiment unexplained features of remodeling chambers and vascular bed of the heart of the Vietnamese pig breeds in the intoxication salts of cadmium and aluminum. Established that masometrycal and planimetrical characteristics intact heart cells with different types of blood supply varies with preserved structural stability in tissue homeostasis, cellular and ultrastructural levels. Found that the effect on the body of aluminum chloride and cadmium appears irregular, disproportionately hypertrophy and dilatation chambers of the heart, which increases the relative amounts of stroma, affected cardiomyocytes, stromal-cardiomyocytic ratio, decrease the capillary- cardiomyocytic relation, thickens the walls of arteries, narrowing them lumen, narrowed arterial and venous expanding links microcirculatory bed, changing secretory activity mioendocrine cells of left and right atria. Revealed that structural change is dominated by the action of cadmium chloride in the left ventricle and at most left coronar type of blood supply. It is shown that prolonged injection of experimental animals cadmium chloride and aluminum leads to a pronounced decrease in relative volume changes in secretory granules and relations between their types, characterized by a decrease in interest young, mature and a pronounced growth diffusing granules in mioendocryne cells of atria.In the experiment unexplained features of remodeling chambers and vascular bed of the heart of the Vietnamese pig breeds in the intoxication salts of cadmium and aluminum. Established that masometrycal and planimetrical characteristics intact heart cells with different types of blood supply varies with preserved structural stability in tissue homeostasis, cellular and ultrastructural levels. Found that the effect on the body of aluminum chloride and cadmium appears irregular, disproportionately hypertrophy and dilatation chambers of the heart, which increases the relative amounts of stroma, affected cardiomyocytes, stromal-cardiomyocytic ratio, decrease the capillary-cardiomyocytic relation, thickens the walls of arteries, narrowing them lumen, narrowed arterial and venous expanding links microcirculatory bed, changing secretory activity mioendocrine cells of left and right atria. Revealed that structural change is dominated by the action of cadmium chloride in the left ventricle and at most left coronar type of blood supply. It is shown that prolonged injection of experimental animals cadmium chloride and aluminum leads to a pronounced decrease in relative volume changes in secretory granules and relations between their types, characterized by a decrease in interest young, mature and a pronounced growth diffusing granules in mioendocryne cells of atria.

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