Kapustyana I. Part of calcitonin and amylin in the regulation of exocrine function of the liver in rats

The thesis is devoted to the study of the influence of calcitonin and amylin on the exocrine function of the liver in rats. It was shown, that administration of calcitonin in dose 200 ng/kg and 800 ng/kg of body weight increased secreted bile volume, stimulated secretion of the bile acid conjugates and didn’t effect secretion of the free bile acids. Administration of calcitonin in dose 200 ng/kg body weight didn’t effect the composition of the lipids in bile, but the action of the hormone at dose 800 ng/kg body caused weight observed changes in the content of the major lipid components of bile. The Injection troduction of calcitonin increases the concentration of the adenylic system components in bile that may indicate s about the involvement of cAMP as a second messenger into of hormone mechanisms of bile secretion. action. It was shown, that Administration of amylin in at dose 1 mg/kg of body weight doesn’t effect the level of the bile secretion and content of the major groups of cholates in bile. But the action of amylin in at dose 3 mg/kg body weight increases the secreted bile volume and content of tauro- and glycoconjugates in bile acids. Administration of amylin in dose 3 mg/kg body weight changes the content of the bile lipidic components more significant, than the injection of hormone in dose 1 mg/kg body weight. It was shown, that the action of both calcitonin and amylin increases the content of the bilirubin conjugates in bile. These changes lead to an active excretion of the bile pigments. Amylin increases concentration of glucose in the blood compared with control, but does not change influence it compared to the initial indices. It may evidence that amylin promote assist of glucose concentration maintenance at the constant level.