Korobchanska A. Peculiarities of morphogenesis of lower jaw and incisor under the influence of heavy metal salts on organism (anatomy-experimental research)

The thesis is devoted to morphological and functional features of lower jaw and incisor tissue under conditions of simulated exposure of heavy metal salts, finding ways to correct the detected changes. Morphological changes were studied by measuring organometric testes, methods of light microscopy, morphometry, immunohistochemical, electron microscopy, chemical analysis, mathematical and statistical data. It was found, the analysis of the results showed that heavy metal salts have a negative impact both on the bone tissue of the lower jaw and incisor dentin. This appeared by slowing of growth processes in bone and dentinogenesis slowing in incisor. Recovery readaptation period for two months did not lead to the normalization of morphogenetic processes in hard tissues of dentofacial system. In our opinion these significant disorders of morphogenesis were caused by significant violations of the chemical composition of inorganic matrix of lower jaw and tooth dentin due to the accumulation of excessive amount of heavy metal salts ions, which displace the basic component of hydroxyapatite - calcium. The concentration of this macronutrient in bone and tooth dentin significantly reduced in all periods of observation, which led to considerable structural changes in observed organs of dentofacial system and intensification of resorptive and osteoporotic changes as well as the disorders of their morphogenesis and growth. Application of metabolic medicine ossein-hydroxyappatit complex allows to reduce injuries of lower jaw and incisor tissue. Results of the research are applied into educational process of departments of histology, human anatomy of medical institutes of higher education.