Ostapiv R. Taurine influence on energetic processes in animal cells

It was detected, that in I experimental group administration of taurine lead to hypoxic condition which compensated by increase in quantity of red blood cells. In this group increased activity of lactate dehydrogenase. Also in rats of II experimental group increased AST/ALT ratio which points on liver damage. Per oral administration of taurine causes increase in behavioral activity in both experimental groups. The biggest indexes are registered in I experimental group, that may be caused by increase of cytoplasmic AST activity. In this group respiration of brain mitochondria increased when succinate was used as substrate. On the contrary, in rats of II experimental group oxygen consumption of mitochondria decreased at those conditions. Activity of lactate dehydrogenase and antioxidant defense enzymes increased in brain and testes of both experimental groups animals. It testes elevated intensity of peroxidative processes. In thigh muscles of I experimental group animals mitochondrial respiration decreased, although, activity of lactate dehydrogenase is higher than in control. In rats' thigh muscles of both experimental groups intensity of peroxidative processes elevated, which increased activity of antioxidant defense enzymes. In liver of both experimental groups oxygen consumption of mitochondria also increased in 1,5-7 times. This caused intensification of peroxidative processes an increase of antioxidant defense enzymes. Keywords: taurine, mitochondrial respiration, antioxidant defense, lactate de-hydrogenase, behavioral activity, brain, testes, thigh muscles, liver, rats.