Doolah A. Development of composition and technology of complex action soft drug to treat fungal skin lesions

The work is dedicated to the scientific and practical substantiation of composition and technology of soft medicinal forms of complex action in the form of cream with clotrimazole, metronidazole, betamethasone dipropionate, carbamide for treatment of fungal skin lesions complicated by hyperkeratosis. On the basis of physic-chemical properties of the active pharmaceutical ingredients, as well as of nature of pathological process, a cream emulsion of oil/water type was chosen as a carrier (base). Based on literature analysis as an oil phase of the emulsion vaseline oil at a concentration of 20 % is selected. Rheological research of model emulsions was conducted in order to select the emulsifiers for stabilizing the emulsion of the cream base. Best measures were provided by emulsifier number 1 in an amount of 5 %. As a result of physic-chemical studies hydrophilic non-aqueous solvent- polyetilenoxide-400 and glycerol were selected to form the basis and their concentration, which amounted to 10 %. Studies (methods in vitro and in vivo) have established an optimal concentration for active ingredients Betacarboclomet drug (clotrimazole 0,8 % metronidazole 0,5 % betamethasone dipropionate 0,065 %, carbamide 10 %) and Clotricarb drug (clotrimazole 1 %, carbamide 5 %).