Коlesnikova V. Development of contain and technology of a crеme for the medication of dermatological diseases, caused by demodex.

The dissertation is dedicated to the development of contain and technology of a cr?me for the medication of dermatological diseases, caused by demodex. It was first, according to the studying results for the physico-chemical, biopharmaceutical, pharmacotechnological, microbiological and pharmacological investigations, developed the complex action cream contain based on metronidasol, troxerutine and salicylic acid to medicate the dermatological diseases, complicated by the Demodexfolliculorum. The complex of physico-chemical, biopharmaceutical, pharmaco-technological, microbiological and pharmacological investigations proved the medicine technology. The quality control indexes are offered, the methods of metronidasol, salicylic acid and troxerutine HQLCG identifying. The drug keeping conditions and expiration date are defined. The pre-clinic investigations identified the anti-microbic, anti-inflammatory and capillary strengthening activity of the developed cream.