Slobodyanyk L. Role of hydrogen sulfide and nitric oxide in regulation of liver blood flow

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U002696

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

01-06-2016

Specialized Academic Board

Д 26.001.38

Taras Shevchenko National University of Kyiv

Essay

The experimental results indicate that hydrogen sulfide (H2S) and nitrogen oxide (NO) are actively involved in the regulation of liver blood flow. This is evidenced by the vasodilatation of intrahepatic vessels caused by the intraportal injection of L-cysteine (precursor of synthesis of H2S) or NaHS (donor of H2S) and L-arginine ( precursor of synthesis of NO). In response to the intraportal introduction of DL-Propargylglycine (cystathionine gama-lyase inhibitor, CSE) observed increased blood pressure in portal vein and reduce blood flow in the liver tissue and its blood supply.

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