Object of research: adaptive processes in the organism of pigs and functioning of intestinal immune barrier under the influence of stress weaning at different periods of postnatal ontogenesis and using of additives "B-glucan" and "Biovir." The purpose of research - to find out the state of the physiological mechanisms of adaptation and intestinal immune barrier of pigs in the different stages of stress weaning from the sow and the using of additives "B-glucan" and "Biovir." The methods of research: clinical and physiological, hematological, immunological, microbiological, morphological, histological, statistics. Scientific novelty: For the first time it was conducted a systematic study of the functional state of the organism and intestinal immune barrier of piglets of Poltava Meat Breed in critical periods of ontogenesis under the influence of stress weaning from sows. It was investigated that the development of technological stress in the body of piglets is accompanied by a decrease in a number of erythrocytes and certain types of leukocytes, humoral and cellular links of non-specific resistance, some indicators of protein metabolism at the stage of anxiety and resistance, compared with the period before weaning. Entered further study of reactivity of the intestinal immune barrier, which under the influence of technological stress is demonstrated by reduction of the number of bifidobacteria and lactobacillus, by increase of the number of E. coli in cavity and mucose of small intestine, by destructive changes of morphological parameters of lymphoid nodules, their cellular desolation in the structure of yeyuno-ileal payers patche, especially at the stage of anxiety and resistance by H. Selye. It was found that the feeding with fodder additives "B-glucan" and "Biovir" during preparatory period to the influence of stress weaning and at different stages of stress development (20 and 60 days after weaning) promotes the increase of main indices of hematopoiesis, the increase number of bifido- and lactobacilli in the intestinal cavity, the intensity of B- lymphocytopoiesis, the development of plasma reaction and saturation of lymphoid nodules with immunocompetent cells. It is proved the advantage of using the fodder additive "Biovir" in piglets feeding which helps to identify the negative effects of stress and demonstrates the increase of adaptive capacity of piglets organism and growing of their body's weight during weaning from the sow. Is offered: On the basis of clinical and physiological, hematological, immunological, microbiological, morphological, histological and statistical indicators new results are received, which are concerned physiological and immunological mechanisms of functional adaptation of piglets to the influence of stress weaning at different stress periods and scientifically grounded new approaches to effective prevention of negative action of technological stress on animals under the using of fodder additive "B-glucan" , based on beta glucan "B-glucan" and fodder additive "Biovir", based on low molecular weight peptides cell walls of bacteria. Introduced It is recommended to use fodder additive "Biovir" in the amount of 10 mg / kg body weight per day every day from 5- to 45-days old piglets for increase adaptive capacity of the organism of pigs of Poltava Meat Breed at an early age and prevention of stress phenomena associated with weaning from the sow, regrouping from different nests to further maintenance during the feeding and rearing of the restructuring of the diet. The results of the study of the adaptive mechanisms of intestinal immune structures of pigs should be used in the learning process for such disciplines as "Normal and Pathological Physiology", "Histology", "Immunology and Microbiology" for students of the Faculty of Veterinary Medicine of Ukrainian Universities III-IV accreditation level and in scientific research work.
