Strashok O. Substantiation and differentiated application of integrated approaching to treament of patients with alcohol withdrawal syndrome

The work is dedicated to the specific features study of alcoholic withdrawal syndrome (AWS) on the background of ozonetherapy based on the analysis of clinical-psychopathological picture and the results of the complex dynamic study of the adaptation mechanisms of free radical oxidation, antioxidant protection and maintenance of neurotransmitters. Research was conducted on the basis of MHA "Regional narcological dispensary" in Kharkiv. We were examined 156 men aged 20 to 50 years with АWS. In the main group (107 men) with standard treatment of AWS we use ozonated refined olive oil was prescribed orally for 7-10 days . The control group consisted of 49 patients. After examination it was found out that 55,0% of patients AWS was formed on the background of nonspecific adaptive stress reactions, as confirmed by the influence of sympathetic division of the autonomic nervous system, which are determined by the reduction of temporal and spectral parameters of heart rate variability of formation of AWS occurs on the background of pronounced disturbances in the excretion of monoamine (catecholamine and serotonin). The AWS is characterized by processes' intensification of free radical oxidation of proteins and lipids, decreased activity of enzymatic component of antioxidant defense. The use of ozonized olive oil in the complex treatment of patients with AWS enabled to a greater extent of relieving the clinical symptoms and decreasing signs of oxidative stress due to the compensatory increase of glutathioneperoxidase activity, reducing the tensions in the metabolism of catecholamines and increasing the capacity and spectrum of heart rate variability.