Klimanskyi R. Optimization of treatment of infants with malformations of the gastrointestinal tract associated with per-sistent intracellular pathogenst.

Object - persistent intracellular infections in children with congenital malformation of the gastrointestinal tract (CM GT); goal – improve the results of treatment of newborns with congenital malformations gastrointestinal tract associated with persistent vnut-intracellular pathogens by improving schemes preoperative and postoperative treatment and rehabilitation; methods – clinical, laboratory, instrumental, serological, molecular biological, immunological, morphological, statistical; results –the first time for, on the basis of molecular biological and serological methods of study, was to determine the prevalence of infection TORCH-infections in the digestive tract of children with CM GT; studied the degree of activity of the infectious process; the species composition and the frequency of occurrence of pathogens TORCH-infections; established a significant association between infection with the child persistent intracellular pathogens and the presence of CM GT; the first time for studied particularly interleukin and interferon status in children with congenital digestive tract, which allowed to establish elevated levels of proin-flammatory interleukin (IL 1, IL 2, IL 6), TNF-? and IFN ? and reduced anti-interleukin (IL 8, IL 10) IFN ?, as well as set the dependence of the degree of immune imbalance of active infection caused by persistent intracellular pathogens; developed and improved treatment regimens etiopathogenetic TORCH-infections in the digestive tract of children with CM GT in the perioperative and rehabilitation period; branch – medicine