Oleshko O. Anatomical and experimental study of chitosan membrane application for treatment of skin mechanical defects in the age aspect

Features of reparative regeneration of the skin mechanical trauma was studied using modern methods of research based on the phases of wound healing in the age aspect. We found significant difference between traditional approaches and the use of chitosan membranes for the treatment of mechanical skin wound. Experimental wound dressings have shown pronounced therapeutic effect. It revealed that chitosan enhances macrophage response, which indicates by activation of phagocytosis, which in turn, reduces microbial contamination of trauma surface. Reducing the surface area of the defect in the application of chitosan was significantly higher than without the treatment. It was found that the healing of skin wounds under the influence of chitosan leads rapid formation of granulation tissue with well-developed vessels, and a large number of polymorphic cells and fibrous structures.