Bilash V. Comparative morphology of human submandibular salivary glands and some laboratory animals.

The thesis presented the scientific problem solution regarding investigations of topography, adjacent tissues and morphology of the human submandibular salivary glands and some laboratory animals in a comparative-species aspect for determining the most suitable animal species for experimental modeling of their diseases and preclinical testing of corrective factors. The structural organization of the submandibular salivary glands in comparative-species aspect has been studied with the complex of modern, adequate techniques. The macrometric, morphometric, histological, histochemical, lectinohistochemical and immunohistochemical features of the submandibular salivary glands structure have been determined and similarity and structure differences have been identified. The histocytotopographic features of immunocompetent cells involved in local immune protection have been determined and the structural elements of submandibular salivary glands with high proliferative activity which provide the physiological regeneration of the gland have been detected. It was proved, that the morphology of the submandibular salivary glands depended on the species origin. Hydrocarbon determinants have been detected and evaluated on the structural elements of the human submandibular salivary glands and some laboratory animals. The topography and features of the adjacent tissues of submandibular salivary glands of man, dog, rats, rabbits, guinea pigs have been studied in detail and the reasonable operative accesses for surgical interventions modeling in various pathological conditions have been substantiated.