Shevchenko Y. The physiological role of peptides that control eating behavior in regulating the energy balance of young people with overweight. - On the rights of the manuscript.

The dissertation is devoted to solving the scientific problem of physiology, which is to determine the physiological role of peptides that control food behavior in the regulation of energy balance in physiological conditions and in conditions of increased nutrient intake in order to substantiate the use of the method of physiological correction of positive energy balance with metered physical activity and caloric restriction of dietary ration. The features of eating behavior and the formed idea about the quality of life of people with normal and high body mass among the students are determined. In subjects with high body mass, all three types of behavioral disorders with a predominance of a limiting and significant percentage of violations of the external type, in persons with normal body weight, by external and restrictive types, have been identified. The restrictive type of food behavior is determined by the most pathogenetical important factor affecting the formation of body weight in young people. An increase in body weight contributes to a possible decrease in the quality of life by indicators of role-based physical functioning, pain and an indicator of the overall physical component of health. It was determined that energy consumption by persons with an increased body weight exceeded the control group's figures for the total mass of consumed substances and energy value and daily needs according to the level of basic energy exchange and physical activity. It is proved that under the conditions of the excess energy transfer in the organism, changes at the level of the central regulatory mechanisms for supporting energy homeostasis are determined by an increase in the production of the orexigenic AgRP neuropeptide, the formation of insulin resistance and the appearance of signs of chronic systemic inflammation. For the first time, the formation of individuals with a normal mass of direct correlation between the level of anorexigenic neuropeptide CART and insulin, in persons with a high mass - between the level of the orexigenic neuropeptide AgRP and insulin was found. It has been proved that changing lifestyle with the use of metered exercise and reducing the caloric content of the diet raises a significant decrease in the level of AgRP, reduction of visceral fat stores, increased high density lipoprotein, decrease in the level of TNF-? and the disappearance of insulin resistance.