Omelchenko I. Development of the medicine with sedative action on the basis of α-bromisovaleric acid ester and mint oil in the solid form

The thesis is devoted to the development of the composition and technology of sublingual tablets with sedative action, that are a pharmaceutical alternative to the medicinal form of the medicine “Corvalol”, drops for oral use. The method of transfer of liquid active substances into a solid state by encapsulation at the molecular level using cyclodextrins is substantiated.The technology of obtaining inclusion complexes of ethyl ether of α- bromisovaleric acid and mint oil with β-cyclodextrin has been developed. Methods of their identification with the help of thermogravimetric analysis and near-infrared spectroscopy are offered. Based on the physical, chemical, pharmacotechnological, microbiological and pharmacological researches, the composition and the rational technology of tablets “Corvalol” are developed. The methods of standardization of the medicine have been developed, stability of tablets “Corvalol” has been studied in the process of storage and the term and conditions of their storage have been determined. The normative documentation for the medicine (technological regulations, quality control methods) was developed and introduced into industrial production at Farmak Joint-Stock Company