Zhernokliov U. Seasonal differences in the reaction of bone tissue to exogenous melatonin and normobaric hypoxia of the sanogenic level

In the thesis, according to the goal, the mechanisms of bone tissue remodeling were studied depending on the season and arterial pressure of animals. The use of both exo- and endogenous corrective effects provides the possibility of stimulating the processes of physiological remodeling of bone tissue. It is shown that the introduction of exogenous melatonin to the rats of the Wistar line in autumn is accompanied by simultaneous increase in the activity of both resorption and formation of new elements of bone tissue. In spring, under the same conditions of the experiment unbalanced processes of destruction and restoration of bone tissue were observed. The obtained data allow to focus attention on seasonal changes in the reactivity of bone tissue and its dependence on arterial pressure and thyroid activity.Therefore, in order to achieve the positive effect of biophysical and/or pharmacological factors on bone remodeling, the general physiological state of the organism (blood pressure) and its sensitivity to seasonal variations should be taken into account.