Аslanian M. Development of the composition and technology of tablets for treating of the hepatobiliary system violations

The thesis is devoted to the development of composition and technology of the original drug, containing a combination of vegetable substances flamin (0.05 g) and lavender oil (0.02 g) for complex treatment of the liver and bile ducts diseases. Lavender oil in combination with flamin has allowed expanding the spectrum of action of the latter due to its own antibacterial, choleretic, antiseptic, antispasmodic and other properties. Based on the results of physical, physico-chemical, pharmaco-technological and microbiological studies, the composition has been substantiated and the technology of separate preparation of masses for Lavaflam tablets for the complex treatment of the hepatobiliary system diseases has been developed. A mixture of lavender oil was obtained by solid phase method, as auxiliary substance β-CD was used. When obtaining flamin mixture, the PARTEK M 200 mannitol, which improves the flowability value, was used. The properties of the drug "Lavaflam" have been investigated, methods of quality control have been proposed, storage conditions and shelf-life have been determined. The projects of the QCM and the technological regulations for the production of Lavaflam tablets in the industrial environment based on the pharmaceutical company Zdorovya have been developed.