Radoga R. Morphological changes of the left ventricular myocardium during the early terms after the skin burn injury and under conditions of colloid-hyperosmolar solutions (experimental study)

The dissertation is devoted to the preclinical study of morphological changes in rats' myocardium during the early stages after burn injury of the skin and the use of colloid-hyperosmolar solutions of lactoproteinum with sorbitol and HAES-LX-5 %. During the study, it was found that macrometrical and histological changes in the rats' myocardium after the skin thermal injury (II-III degree) and intravenous infusion of lactoproteinum solution with sorbitol and HAES-LX- 5 % were manifested to a much lesser extent than the experimental animals infused with 0, 9 % NaCl solution. By the way, the introduction of combined hyperosmolar solutions leads to a decrease of endogenous intoxication, improvement of cell cycle (S-phase, G2 + M phase, phase G0G1) and DNA fragmentation (SUB-G0G1 interval) in the 1st, 3rd and 7th day after the beginning of the experiment. Intravenous infusion of the HAES-LX- 5 % solution to animals without burn injury did not affect the level of endogenous intoxication and did not lead to morphological changes in the myocardium both at the macro and microscopic level of the structural organization. The results of the work can become the theoretical basis for the development of new methods of infusion therapy against of severe thermal effects.