The dissertation presents data on the monitoring of the epizootic situation regarding bacterial diseases of poultry in the north-eastern region of Ukraine. It was established that among isolated conditionally pathogenic microflora enterobacteria predominate namely Escherichia - 34,0%, and Salmonella - 16,0%. According to the serotyping of isolated cultures of Escherichia and Salmonella, 11 serovars of each were allocated. The following serotypes belong to E. coli: O35, O157, O55, O78, O7, O1, O4, O9, O41 O8, O2. By Salmonella, such as: S. enteritidis, S. pullorum-gallinarum, S. typhimurium, S. anatum, S. london, S. infantis, S. bredeney, S. tsioque, S. jawa, S. montevideo, S. kentyki. Analyzing the antibiotic resistance of salmonella and escherichia to 32 antibiotics, it was found that the greatest resistance was shown to the groups of penicillins, linсosamides, tetracyclines and aminoglycosides. As an alternative to antibiotics, citrate Ag and Zn had been proposed to prevent escherichiosis and poultry salmonellosis. It had been established that citrate Ag possessed bactericidal action against E. coli O2, S. typhimurium, P aeruginosa, zinc citrate - E. coli and S. epidermidis respectively. The extremely safe concentrations of citrates had been determined based on the results of toxicological studies on white rats. The acute toxicity value for intragastric administration of Ag citrate for white rats (female) DL50 was 208.0 ± 35.0 mg / kg body weight, and males 216.0 ± 67.0 mg / kg. For intragastric administration of citrate Zn, DL50 was 200.0 ± 16.75 mg / kg for males and 195.84 ± 4.14 mg / kg for females, that the results of studies according to State standard 12.1.007-76 belong to the 4th class of low-toxic substances, which, when externally and internally introduced into the body of experimental animals, had no apparent clinical signs of intoxication of local-irritating and skin-resorptive action on the skin surface of the investigated animals. Therapeutic efficiency of Ag and Zn in the dose of 15 g / 250 sm3 of water for 5 days after experimental Escherichia had been shown, which allowed obtaining 100% preservation of chickens other than antibacterial preparations (florfenicol and amoсsocillin clavulanate), where the percentage of recovered chickens had been 90%. In experimental salmonellosis, the efficiency of citrate ions in combination with organic acids in a dose of 15 g +5 org. acids g / 1 dm3 of water, where the survivors of chickens had been 90% compared with the groups, where the drugs had not been used, only 50% of chickens survived. After prescribing Zn and Ag drugs to chickens suffered on the Escherichia the decreasing of disease had been observed: erythrocytes -in 2.3 times, leukocytes - in 2-2.2 times, eosinophils - in 1,5-2,2 times, monocytes - in 1,7-1,5, lymphocytes - in 2,7 - 5,0 times, basophiles - in 1,8 times according to the control (5,60 ± 0,78%; Р ˂0,05). It probably (Р ˂0,001) increased of bactericidal activity of serum in 2,5 times and lymphocytic activity of serum in 5,3 times in comparison with control (5,25 ± 0,42; Р ˂ 0,001). In salmonella chickens, the normalization of the number of red blood cells and leukocytes had been observed during the combination of citrate Ag and Zn with organic acids(3:1:200 sm3). Thus, the number of erythrocytes decreased by 2.5 times, leukocytes -in 1.6 (Zn + org. acids) and 1.8 (Ag + org. acids) times, according to control (62.24 ± 1.40; P ˂0.05).The level of monocytes had been decreased by 1,3 (Zn + org. acids) and 1,8 (Ag + org. acids) times, eosinophils - in 2 and 1,8 (Zn + and Ag + org. acids) times. The level of lymphocytes was 3.5 and 3.3 times lower than control (60.23 ± 2.14%; P ˂0.01). The level of hemoglobin was in the range in all experimental groups (91.82 ± 2.05 and 90.84 ± 2.23 g / l 93.40 ± 1.99 g / l and 89.94 ± 2.28 g / l). In the case of bactericidal activity of serum its growth had been observed at 2.2 (Zn + org. acids) and 2.3 (Ag + org. acids) times compared with control (26.40 ± 0.62) % lymphocytic activity of serum increased by 4.6 and 4.7 times. Study of the effectiveness of the broad spectrum antibacterial agent «Saroflox» for the treatment of escherichia and salmonellosis. In the course of this experiment, it was found that the experimental sample of the drug «Saroflox» showed healing and expressed prophylactic properties at a dose of 0.24 mg / dm3 of water for a further five days during the course of escherichia colitis and poultry salmonellosis, as well as its application increased the live weight of broilers at 36-day age by 9.3%, and preservation - by 1.4%.
