Havryshchuk Y. Structural-functional rearrangement of vessels and cortex of rats brain at experimental occlusion of the aorto-iliac segment and its recanalization

The dissertation is devoted to the establishment of peculiarities of the rearrangment of vessels and cerebral cortex of rats in the in experimental occlusion of the aorto-iliac segment and its recanalization, as well as in the application of correction of reperfusion changes. In the dynamics of adaptive-compensatory processes, the following types of reactions are distinguished: the alterative - up to the 3rd day of observation with the development of the hydropic dystrophy of neurons against the background of vasodilatation of vessels of medium diameter with simultaneous vasoconstriction of small arteries; adaptive-compensatory - 3-7 days of the experiment with stabilization of the morphofunctional state of the hemomycrocirculatory bed and cytoarchitectonics of the cerebral cortex and recovery - from the 14th to the 28th day of observation with the backward development of alterative changes. Rehabilitation of the abdominal aorta on the first stages is accompanied by a deepening of changes in the vessels and brain cells. Application of Actovegin allows to reduce the degree of severity of reperfusion changes in the recovery period.