Babiy O. Development of composition, technology and investigation of semi-solid preparations for treatment of herpes infection.

Objects - tilorone, menthol, еxcipients, basics of semi-solid preparations, experimental samples of semi-solid preparations, ointment and gel with tilorone and menthol; aim – development of the composition, technology and research of the semi-solid preparations for the treatment of herpes infection; methods – general scientific, organoleptic, physical, physico-chemical, pharmaco-technological, biopharmaceutical, biological and statistical; novelty - for the first time there has been physical, physico-chemical, pharmaco-technological, biopharmaceutical and biological researches it was developed the optimum composition and technology ointment and gel with tilorone and menthol for local treatment of herpes infection, results – the optimal composition and technology of the ointment and gel with tilorone and menthol have been theoretically substantiated and experimentally proved; the methodology of identification and quantitative recognition of active pharmaceutical ingredients in developed preparations have been worked out and methyl parahydroxybenzoate and antimicrobial preservatives in gel; the shelf-life and storage conditions for the ointment and gel have been defined; structural-mechanical, microbiological, toxicological and pharmacological properties of the developed ointment and gel with tilorone and menthol have studied; the approbation of a technology and control techniques for the quality of a semi-solid preparations in industrial production have been conducted; introduced - into the educational process of higher educational institutions; branch - pharmacy.