Hula V. Structural changes of the stomach fundus division under conditions of dehydration of the organism (anatomical and experimental research)

The dissertation is devoted to studying the changes of structures of the stomach fundus division at the macro-, micro- and ultrastructural levels under conditions of different types and degrees of dehydration of the organism of laboratory rats and the possibility of correction of the structural changes of the stomach tissues using ethylmethylhydroxypyridine succinate. It was revealed the greatest decrease of the stomach volume by 78.86 % (p < 0.000 1), the thickness of the stomach wall by 30.06 % (p < 0,000 1), the mucous membrane by 14.96 % (p = 0.009 7), the muscular membrane by 41.71 % (p = 0.000 2), the serous membrane by 37.31% (p < 0.000 1), the cross-sectional area of the cytoplasm of glandulocytes under conditions of severe general dehydration of the organism relative to the control group of animals. The gastroprotective action of ethylmethylhydroxypyridine succinate was manifested in decreasing of desquamation and better preservation of the structural organization of gastric glands, general decrease in the number of cells with the consolidation of nuclei and cytoplasm, an increase in the number of mitochondria with the typical structure and secretion of the glandular cells in conditions of all types of dehydration, reduction of edema in periglandular spaces of the basal parts of glands under conditions of intracellular dehydration, reduction of the frequency of occurrence of the cyst-like cavities in the gastric glands and signs of cellular edema in conditions of extracellular dehydration of the organism.