Darzuli N. Development of composition, technology and research of tablet formulations of Pyrola rotundifolia extract

Objects – pyrola rotundifolia leaf, dry extracts of pyrola rotundifolia leaf, excipients, compression mixture and tablets based on them; aim – substantiation of the composition, technology development and research of the tablets based on the extract of pyrola rotundifolia leaf for the treatment of the infectious diseases of the urinary system; methods – general scientific, organoleptic, physical and chemical, pharmaco-technological, microbiological, biological, mathematical and statistical; novelty – the pharmaceutical development of a new formulation drug in the form of tablets based on standardized extract of pyrola rotundifolia leaf intended for the treatment of the infectious diseases of the urinary system has been carried out; results – the technology of dry phytoextracts has been developed, their physical and chemical and pharmaco-technological studies have been carried out with usage of the mathematical planning of the experiment, the optimal composition and technology of the tablets based on standardized dry extract of pyrola rotundifolia leaf have been theoretically substantiated and experimentally proved, the methods of qualitative and quantitative analysis for the developed tablets have been worked out, the shelf-life and storage conditions for the tablets have been defined, pharmacological properties of the developed tablets have been studied, the approbation of the technology and control techniques for the quality of dry phytoextracts and tablets based on them have been conducted in industrial production; introduced – into the educational process of higher educational institutions, LTD «Ternopharm»; branch – pharmacy.