Petrenko V. Scientific Reasoning of the Correction of Substance Exchanges and Natural Immunity of Turkey Under the Conditions of Commercial Growing

The thesis is dedicated to the research of the immunity and turkey liver condition under the conditions of commercial production and experimental substantiation of the effectiveness of use of the immune modulator called «Biovir» and hepatoprotector «Hepatonic» as well as their joint use in the conditions of commercial production of turkey. The nature of changes in the immunity and turkey liver has been established. The negative influence of factors of commercial production and biological factors on the homeostasis of the organism has been proved. Under the influence of industrial production factors and the effect of biological factors on the 42 day of turkey age there is a strain of regulatory, homeostatic and protective mechanisms of the organism. Humoral immunity of turkey in intensive production was characterized by functional deficiency of T-cell system, weakening of T-helper activity which leads to a decrease in the synthesis of antibodies, T-cell activity, which means that there is secondary immunological deficiency causing partial loss of immunity (р<0,01). The feasibility of the immune modulator called «Biovir» and hepatoprotector «Hepatonic» as well as their joint use in the conditions of commercial production of turkey has been proved. The turkey of the experimental group showed organism metabolic function improving, reduction of the negative influence of abiotic factors. Consumption of immune modulator called «Biovir» and hepatoprotector «Hepatonic» positively influenced the processes of hepatocyte reparation and increased their protein synthesizing function. In conditions of scientific and production experiments the usage of immune modulator called «Biovir» and hepatoprotector «Hepatonic» contributes to an increase in pre-slaughter body mass of males by 3.5 % compared with the control bird the livestock safety index is up to 93.4 % against 91.8 % in control, and the additional revenue from the sale of turkey meat is 21.43 UAH at 1 UAH expenses.